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Scientists develop breakthrough approach to detecting endometriosis in menstrual blood

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Scientists have developed a powerful new approach to detecting endometriosis which could transform how the disease is researched, diagnosed and treated.

In a world-first clinical study, scientists tested a pioneering diagnostic process which involves directly isolating menstrual blood-derived stem cells (MenSCs) from menstrual blood samples for analysis, rather than analysing cultured cells.

Scientists believe MenSCs are the cells that drive lesion formation in endometriosis.

Culturing the cells alters their make-up; whereas freshly isolating the cells without culturing preserves their molecular integrity, enabling a deeper and more direct view into how endometriosis behaves than ever before.

Dr Francisco Carmona is former president of the International Society of Endometriosis and Uterine Disorders, head of the Endometriosis and Uterine Transplant Unit at Hospital Clínic Barcelona, and co-author of this study.

The researcher said: “This study marks a significant leap forward in our mission to understand the biology of endometriosis.

“It has far-reaching implications: the methods tested could power the development of non-invasive patient stratification and diagnosis, better treatments and personalised care pathways, transforming the lived experience of patients with endometriosis and how we approach their care.”

In this landmark study, scientists were the first to analyse freshly isolated MenSCs using a process called DNA methylation profiling, which is already widely used to diagnose cancer.

They achieved an accuracy rate of 81 per cent and were clearly able to distinguish participants with endometriosis from those without.

The approach means scientists can use readily available menstrual blood samples to accurately diagnose and categorise endometriosis: a significantly less invasive process for patients than the current diagnostic gold standard, which involves a surgical procedure called a laparoscopy.

It also enables scientists to uncover critical information about the disease that can’t currently be provided by diagnostic imaging or biopsies.

Scientists hope the new technology will enable clinicians to detect endometriosis far earlier and without surgical intervention, reducing endometriosis diagnosis times from an average 7-10 years to just a few weeks.

The team also hopes to lay the foundation for the development of targeted therapies to treat different types of endometriosis.

Their approach could enable clinicians to stratify patients based on how the disease is behaving, and give patients access to targeted treatments before the condition has advanced.

The study was carried out by researchers at Hospital Universitario Insular de Gran Canaria and Hospital Clínic Barcelona – a leading centre in endometriosis care and research.

It was led by endogene.bio: a Paris-based precision medicine organisation on a mission to turn cutting-edge science into clinical tools that can close the female health gap. The endogene.bio team comprises world-leading experts in epigenetics, gynaecology, immunology and computational biology, many of whom also suffer from endometriosis.

Dr María Teresa Pérez Zaballos, co-founder and CEO at endogene.bio, said: “We wanted to design something that we as patients, but also as researchers, wished had existed.

“By accessing the molecular signals in menstrual blood, we’re unlocking information about endometriosis activity that was previously only available through surgery.

“Our approach shows DNA methylation profiling is a reliable, non-invasive way to diagnose endometriosis.

“Our findings also support the use of menstrual blood as a stable diagnostic sample.

“Many members of our team are endometriosis patients themselves, myself included. Our firsthand understanding of the diagnostic delays, clinical blind spots, and emotional toll of endometriosis shapes every decision we make, from sample collection design to clinical priorities.

“This is a company built by scientists who understand the molecular complexity of the disease and by patients who know exactly where medicine has fallen short.”

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The NHS doesn’t have a productivity problem: It has a precision problem

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By Dr Melinda Rees, CEO, Psyomics

Spend enough time in the NHS and you stop flinching at the word “productivity”.

You hear it in every strategy document, every board meeting, every government announcement.

And almost every time, it means the same thing: do more with less.

It’s the wrong framing.

After 25 years working in and around clinical services – from NHS leadership to service delivery in the independent sector to where I am building technology that works with NHS mental health services – I’d argue it’s part of why progress has been so hard to achieve and sustain.

Productivity in healthcare shouldn’t mean squeezing more out of an already over stretched workforce.

It should mean something more precise: delivering greater value per pound by protecting and deploying finite clinical expertise intelligently.

That distinction sounds subtle. In practice, it changes everything about how you approach the problem.

The demand side of this equation isn’t going to get easier.

Multi-morbidity is rising. Mental health need is growing. Cases are more complex, and patient expectations – rightly – are higher.

The assumption that we can recruit our way out of this is understandable but wrong.

Training pipelines take years. Financial resources are finite. Even in an optimistic scenario, workforce expansion alone doesn’t close the gap.

So, the real question isn’t how do we get more clinicians. It’s whether we’re deploying the ones we have with maximum precision.

And honestly, in most services, the answer is no.

  • Clinical time – the most valuable finite resource in the system – is routinely lost to things that have nothing to do with clinical decision-making.
  • Administration.
  • Repetitive documentation.
  • Poor workflow.
  • Systems that don’t share information across boundaries.
  • Inconsistent and variable clinical decision-making.
  • Referrals that shouldn’t have reached a specialist clinic in the first place.
  • Reactive care models that wait for deterioration rather than anticipating it.
  • Gathering baseline information that could have been collected earlier, more consistently, and without the clinician in the room.

Meanwhile, the waiting list grows.

This isn’t a motivation problem or a workforce culture problem. It’s a system design problem.

And it’s solvable – meaningfully – if we’re willing to rethink how technology fits into the picture.

The challenge with digital implementation in the NHS has rarely been the technology itself – it’s been layering new tools onto processes that were already under strain.

A new system that digitises an inefficient workflow is still an inefficient workflow.

Real productivity gains come when technology is used to redesign how work actually happens – not just record it.

In practice, that means four things.

First, automating the tasks that don’t require clinical expertise – structured data capture, digital triage, standardised assessment pathways.

Every minute saved on documentation is a minute returned to care. At scale, those minutes add up fast.

Second, bringing patients into the process earlier.

When a patient contributes structured, meaningful information before their first appointment, the clinician and patient have a great head start.

Better routing, smarter questions, faster and safer decisions, quicker access to the right treatment.

Third, monitoring caseloads intelligently.

Utilising tools that flag deterioration or signal when a care plan needs to change, rather than waiting for a crisis to trigger a review.

Finally fourth, making sure every appointment actually advances care. That sounds obvious.

In practice, without recorded structured outcome data, it’s surprisingly hard to know.

None of this requires drastic AI transformation or futuristic promises.

Some of the biggest gains come from making simple workflow tasks consistent and seamless – the kind of unglamorous operational improvement that doesn’t make headlines but compounds quietly across thousands of patient interactions and increases productivity.

A 1-2 per cent productivity gain per clinician sounds modest.

At NHS scale, across millions of appointments, it isn’t. It’s the difference between a system grinding and one with genuine headroom to breathe.

It’s the difference between your close relative being able to get an appointment when they genuinely need one or languishing on a waiting list with little hope.

I think about this a lot through the lens of mental health services specifically, where I’ve spent most of my career and where Psyomics works.

Mental health has historically been underfunded and under-prioritised – something that disproportionately affects women, both as patients and as the clinicians and carers holding those services together.

The pressure to do more with less lands hardest here. And the argument that productivity means working harder is, in this context, particularly damaging.

Burnout in mental health services isn’t a footnote. It’s a crisis within a crisis.

The better argument – the one I’d like to see shape NHS policy – is that productivity means precision.

Precision in how we route patients. Precision in how we use structured data to reduce variation and improve decisions. Precision in how we protect clinical time for the work that only a skilled clinician can do and loves to do.

That’s not a technology story, exactly. It’s a system design story, in which technology plays an enabling role.

The NHS doesn’t need to do more with less.

The goal isn’t harder-working, exhausted clinicians – it’s smarter-working, compassionate enabled clinicians, and patients who are seen sooner.

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Women’s health leaders warn of censorship

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More than 600 women’s health leaders warn social media censorship is restricting medically accurate, life-saving women’s health information.

In an open letter, as reported in the Independent, they said essential health advice was being restricted as posts about menstruation, fertility, menopause, postpartum recovery and sexual wellbeing were being systematically censored.

The posts are frequently misclassified as “adult content” and removed or restricted by automated moderation systems, even though they are educational or medically accurate.

Dr Aziza Sesay, medical doctor and broadcaster, said: “Online censorship perpetuates the narrative that women’s and gynaecological health is inappropriate and should remain taboo.

“This amplifies the embarrassment that already surrounds these topics.

“I often say that women are dying of embarrassment because they’re not coming forward about their problems due to shame, and when they present late, outcomes are poorer.

“Shame and stigma are costing lives.”

A survey by CensHERship, a campaign to tackle the social media censorship of women’s health and sexual wellbeing content, found 95 per cent of women’s health creators experienced censorship in the past year.

Respondents cited rejected advertising campaigns, removal of educational posts, reduced reach on social platforms and a lack of transparent appeals processes.

More than half said they now self-censor their language to avoid being taken down from social media platforms.

The warning comes as leading brands including Essity, Clue, Hertility, Daye and Mooncup join a newly formed coalition, the Women’s Health Visibility Alliance (WHVA), created to challenge what campaigners say is systemic bias in how digital platforms moderate women’s health content.

Clio Wood, co-founder of CensHERship, said: “Women’s and reproductive health content is not a threat to anyone’s safety.

“This is about accurate, life-saving health information being treated as obscene, and about women-led innovation being blocked at scale.

“Our members are tired of self-censoring, of replacing ‘vagina’ with euphemisms, of seeing menopause and fertility treated as taboo.

“Visibility is not a ‘nice to have’. It is fundamental to public health, innovation and gender equity.”

The open letter also called for policymakers to “help bring platforms to the table”, by ensuring “digital regulation addresses gender bias and recognises the public health and economic cost of this issue”.

Deirdre O’Neill, chief commercial and legal officer at Hertility, said: “Hertility has carried out more than 29 research trials and operates within some of the strictest regulatory frameworks in healthcare.

“If a company like Hertility, built on peer-reviewed science and clinical evidence, can be censored while misinformation spreads freely, then the system designed to protect people is clearly failing them.”

Rhiannon White, chief executive of Clue, a period tracking app, said: “Women are the world’s largest health and wellness consumers, controlling the majority of household spending in every market, yet they remain strikingly underserved relative to their economic power.

“This gap creates three systemic pain points: a profound lack of accessible female health knowledge that forces women to self-diagnose, a confusing marketplace filled with unproven products and little evidence-based guidance, and persistent barriers to accessing care.

“Yet when companies such as ourselves and the other members of the Women’s Health Visibility Alliance seek to address these pain points, providing health information that prioritises evidence-based guidance rooted in real science, we are consistently blocked for an array of baffling, unclear and frankly biased reasons.”

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Study reveals how oestrogen protects women from high blood pressure

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Oestrogen helps protect premenopausal women from hypertension by relaxing and widening blood vessels, according to new research examining why women develop high blood pressure less often before menopause.

High blood pressure, also known as hypertension, affects more than a billion people worldwide and is a leading cause of heart disease and stroke.

Premenopausal women are less likely to develop the condition than men or postmenopausal women, but the biological reason has been unclear.

Researchers used a mathematical model of the cardiovascular and kidney systems to analyse how oestrogen influences blood pressure.

The analysis found that oestrogen’s strongest protective effect comes from vasodilation, the process by which blood vessels relax and widen, helping blood flow more easily and lowering pressure in the arteries.

Anita Layton, Canada 150 Research Chair Laureate in Mathematical Biology and Medicine and professor of applied mathematics, said: “Oestrogen is often thought of only in terms of reproductive health, but it plays a much broader role in how the body functions.

“It affects how blood vessels respond, how the kidneys regulate fluids and how different systems communicate with one another.

“What we found is that its impact on blood vessels is especially important for regulating blood pressure.”

The findings may also have implications for treating women after menopause, when oestrogen levels naturally decline.

The model predicted that angiotensin receptor blockers, a common class of blood pressure drugs, could be more effective than another widely used treatment group known as angiotensin converting enzyme inhibitors in treating women with hypertension, even after oestrogen levels decline after menopause.

Layton said her team has spent years developing a mathematical model of women’s kidneys and the cardiovascular system, designed to explore how different biological mechanisms affect blood pressure.

The model allows researchers to test individual effects separately and examine how each influences the body.

“We can turn on one effect, then another, and see exactly how each one affects the body,” Layton said.

She added: “For too long, women’s health, especially older women’s health, has been overlooked by medicine.

“Understanding how age and sex affect the body and, therefore, treatment, is an equity issue.”

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