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Breast cancer could cost UK economy £3.6bn by 2034- report

New report highlights the often unrecognised, wider impacts of breast cancer

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The yearly cost of breast cancer to the UK economy could rise by almost 40 per cent to £3.6bn by 2034, a new report has shown.

The report, published by the cross-party think tank Demos and Breast Cancer Now, has found that breast cancer will likely cost the UK economy as much as £2.6-£2.8bn in 2024.

Exposing the current impact of one of the UK’s biggest health challenges on the lives of those affected and on the NHS, the report has warned that if nothing is done to prevent the current impact of the disease, the annual cost of breast cancer to the economy could rise by almost 40 per cent to £3.6bn by 2034.

The figures represent costs to the NHS, costs to society in terms of productivity loss and the individual costs that people bear, such as out of pocket expenses and the loss of income from work.

The urgent need for action has been further highlighted by the report’s revelation of the true human cost of breast cancer, with wellbeing costs associated with breast cancer estimated to amount to a staggering £17.5bn in 2024.

This figure, around six times higher than estimated economic costs, exposes the often unrecognised, wider impacts of breast cancer, the findings have shown.

Baroness Delyth Morgan, chief executive of Breast Cancer Now said: “These revealing, first-of-their-kind, estimates of the economic and wellbeing costs of breast cancer in the UK show that breast cancer is far from being a ‘done deal’, and the consequences of us failing to act now are dire.

“For 50 years we’ve been supporting anyone affected by breast cancer and funding world-class research. While progress has been made across diagnosis, treatment and care, people diagnosed with breast cancer and their loved ones share with us daily the challenges of living with the disease and how their wellbeing and quality of life have deteriorated.

“While 98 per cent of women diagnosed at stage one survive for five years or more, we cannot afford to be complacent about breast cancer – it’s the most common cancer in the world and cases are rising.”

She continued: “In the UK alone, each year there are around 55,000 new cases and breast cancer causes over 11,000 deaths.

“The outlook for women first diagnosed with stage four, when the cancer has spread to another part of the body and become incurable, is bleak, with around 26 per cent – or a quarter – surviving five years or more. But there are practical steps that can be taken now to help those most affected.

“The Cost of Breast Cancer report is a wake-up call to governments and policymakers across the UK to engage with this growing health crisis and to act now with modelling setting out some of the ways in which this crisis could be tackled, most importantly to transform the lives of those affected by breast cancer, but also to make substantial and much needed cost savings for the NHS and the economy.”

As part of the report, Demos and Breast Cancer Now have set out the results of modelling to demonstrate some of the ways the severe human and financial impacts of breast cancer could be tackled.

The modelling considers the potential impacts of increasing breast screening uptake, introducing more clinical nurse specialists and helping more people return to work after a breast cancer diagnosis.

Lucy Bush, director of research and participation at Demos, said: “Shifting towards a more preventative model of healthcare overall is vital as we face a rising tide of demand for healthcare that firefighting alone will not stem. A preventative approach will reduce the strain on the public purse at the same time as creating a stronger and more resilient population.

“In this report, we show that adopting preventative measures that reduce early death and the impact of the disease have the potential to greatly reduce the cost of breast cancer to the economy and individuals.”

She added: “It is the first study of its kind to evaluate with rigour and depth the true economic costs to the UK economy of breast cancer. It is also the first of its kind to calculate the significant wellbeing costs associated with the impact of the disease on patients and relatives.

“It reveals that as a country we could be doing so much more to reduce the impact of this disease.

“By identifying the true economic costs of breast cancer and where exactly they fall, we have been able to show how targeted upfront investment could improve wellbeing and survival rates and bring down costs in the longer term.”

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Diagnosis

Lung cancer drug shows breast cancer potential

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Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.

PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.

Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.

The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.

In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.

Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.

Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.

Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”

John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”

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Pregnancy

Higher nighttime temps linked to increased risk of autism diagnosis in children – study

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Nighttime temperatures during pregnancy may be linked to a higher chance of an autism diagnosis in children, a recent study suggests.

The research tracked nearly 295,000 mother-child pairs in Southern California from 2001 to 2014 and linked warmer overnight temperatures with higher risk in early and late pregnancy.

Children of mothers exposed to higher than typical nighttime temperatures during weeks one to 10 of pregnancy had a 15 per cent higher risk of an autism diagnosis.

Exposure during weeks 30 to 37 was linked to a 13 per cent higher risk.

 Lead author David Luglio, a post-doctoral fellow at Tulane University, said: “A key takeaway is that we identified specific windows when a mother and her developing child can be most affected by exposures to higher nighttime temperatures.

“This is critical and hopefully can help mothers prepare accordingly.”

The study is described as the first to examine how temperature may affect fetal neurodevelopment, the process by which a baby’s brain and nervous system form during pregnancy.

Extreme temperatures linked to increased risk were classified as above the 90th percentile, meaning 3.6°F hotter than average, and the 99th percentile, 5.6°F above average.

The association held even after researchers accounted for factors such as neighbourhood conditions, vegetation and fine-particle air pollution.

The study could not account for other factors such as access to air conditioning. Researchers did not find the same association with daytime temperatures, potentially because people spend more time away from home during the day.

“Heat waves are becoming more frequent, and people may only think of the dangers of daytime heat exposure,” said Mostafijur Rahman, assistant professor of environmental health sciences at Tulane University.

“These results indicate a strong association between high nighttime temperatures during pregnancy and autism risk in children and show that we need to think about exposure to heat around the clock.”

The study did not examine how higher temperatures at night might affect prenatal development, though Luglio said it is possible that warmer nights disrupt sleep for pregnant mothers.

Previous research has suggested insufficient sleep during pregnancy may be linked to a higher risk of neurocognitive delays in children.

“Extreme heat exposure during pregnancy has been linked to a range of adverse health outcomes, including prenatal neurodevelopment delays and complications with an embryo’s development of a central nervous system,” Luglio said.

“The goal of our study was to specifically explore the link between prenatal heat exposure and autism diagnoses for the first time.”

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Entrepreneur

Kindbody unveils next-gen fertility platform

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Kindbody has launched a fertility platform integrating AI with clinical care and patient support for employers and health plans.

The platform will enter a pilot with select Kindbody employer clients in 2026, covering over three million lives, ahead of wider availability in 2027.

Building on the company’s clinical model, the platform aims to improve outcomes and cost efficiency across family-building journeys. It connects Kindbody-owned clinics, partner clinics and an integrated clinical app.

The app offers virtual care across conception, pregnancy and reproductive health, extending through the menopause transition.

Launch features include updates in medication management, third-party reproduction, adoption, pregnancy, men’s health and global programme design.

David Stern, chief executive of Kindbody, said: “With our next-generation fertility platform, Kindbody is redefining what comprehensive, intelligent and affordable family-building care looks like for employers, health plans and patients.

“By unifying best-in-class clinical care, AI-driven intelligence and whole-person support, we are making it easier and more cost-effective for more people to build the families they envision.”

Kindbody has expanded access via its national network of IVF centres, including IVIRMA, Inception Fertility and Ivy Fertility.

A new Fertility Medication Portal is designed to streamline authorisations so medicines can be dispensed on time, giving patients visibility from prescription to coverage, pharmacy fulfilment and delivery tracking.

Through KindMan, men’s health education, digital resources and integrated clinical care are expanding, including hormone management programmes.

Services cover andropause (age-related testosterone decline), erectile dysfunction, low testosterone and other male reproductive conditions.

Specialist fertility care includes semen analysis, diagnostic testing, male hormone panels, genetic testing, surgical sperm extraction and sperm cryopreservation.

Launching in the second quarter, a pregnancy support app will act as a digital companion for expecting and new parents, with resources, interactive tools and clinical assessments to identify social drivers of health and mental health needs during pregnancy and beyond.

Kindbody’s physician-led menopause programme provides consultations with board-certified obstetricians and gynaecologists to diagnose, treat and manage menopausal symptoms, including hormone replacement therapy where appropriate, with support from nutritionists, mental health therapists and pelvic floor specialists.

AI and analytics will be embedded across the care journey. An AI care navigator will guide employees from benefit activation through intake, triage and scheduling.

Tools will track benefits and treatment plans, showing coverage and expected out-of-pocket costs at each step.

AI-supported scribing will assist clinicians with documentation, and a predictor tool will estimate a patient’s likelihood of having a baby across different treatment paths.

In 2027, Kindbody plans a savings model for eligible large employers that it says will guarantee lower total fertility spend while improving clinical efficiency and patient experience.

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