News
Australian healthcare platform secures up to $24m in Series B funding
Brisbane-based Midnight Health is the company behind Australia’s first same-day pharmacy-to-door delivery of emergency contraception
The Australian healthcare platform Midnight Health has secured up to $24m in funding from the health insurance provider nib holdings limited.
Subject to meeting performance hurdles, nib expects to invest a further $9m in Midnight Health in FY24, taking Series B funding to $24m, and total funding since 2021 to $40m. At the closure of the financing, nib will hold equity of 77 per cent in Midnight Health.
The funds will be used to help the business expand, build scale and develop its IT and service platforms, including its women’s health platform Youly.
“This latest investment will allow us to accelerate growth, develop new services and bring our innovative healthcare solutions to more patients across Australia as we work to change the way care is delivered,” said Nic Blair, Midnight Health co-founder and CEO.
“We’re really proud that we reach a large number of people who live in remote regions across Australia and don’t always have access to a GP.
“Midnight Health brings equity to people around healthcare, whether they live in the bush or a big capital city.”
nib Managing Director, Mark Fitzgibbon said: “nib views the range of Midnight Health products and services as key elements in its vision to become as much a health management company as we are a leading health insurer.
“We are gradually building an ecosystem of technologies and assets, such as Midnight Health, which enable people to personalise and seamlessly meet their healthcare needs through nib.
“It’s an exciting and important endeavor, especially when you consider the fragmentation within healthcare.”
Launched in 2021, Youly was the first company in Australia to deliver same-day emergency contraceptive to a patient’s home. It provides consultations and scripts for over 2,000 medications, including the contraceptive pill, menopause, thrush, and skincare treatments.
As many as one in every 233 Aussie women who use the contraceptive pill have been helped by Youly.
The platform also provides advice for women on many areas of healthcare, including the treatment of sexually transmitted diseases.
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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