News
Amara Therapeutics launches virtual urinary incontinence clinic
Digital Therapeutics company Amara Therapeutics has announced the launch of Dry Days Health, a first-of-its kind virtual clinic dedicated to women living with urinary incontinence, one of the most under-treated yet prevalent conditions affecting women worldwide.
Amara Therapeutics is a women’s health company developing digital therapeutics and virtual care solutions for pelvic and bladder health conditions, including urinary incontinence and overactive bladder.
The new virtual clinic is now live in Indiana and Maryland, with plans for rapid expansion across the US in 2026.
For millions of women, urinary incontinence is more than a medical issue, it’s a hidden struggle that affects every aspect of daily life.
From avoiding exercise or social events to worrying about leaks at work or while caring for family, the condition quietly limits confidence, independence, and opportunity.
It’s also one of the leading contributors to anxiety and depression among midlife women, yet too often goes unspoken.
Despite its prevalence, fewer than half of women ever receive specialist care, largely due to stigma, cost, and a shortage of accessible pelvic and bladder health professionals leaving many to manage alone with over-the-counter pads instead of proven, lasting treatments.
Dry Days Health directly addresses these barriers by providing next-day virtual appointments with specialist licensed clinicians delivering personalised, evidence-based treatment plans from the comfort and privacy of home.
Dr Jennifer Bepple is Dry Days Health medical director.
She said: “Urinary incontinence is very common but is not a normal part of aging and women deserve better care.
“With Dry Days, we’re combining the accessibility of telemedicine with the precision of digital health to finally close the treatment gap for women’s pelvic and bladder health.”
Each patient receives one-on-one care from a licensed clinician along with access to Amara’s app-based pelvic health programme, a set of clinically informed exercises, education, and tracking tools designed to help women strengthen their pelvic and bladder health and stay engaged in their recovery journey.
Together, these components form a comprehensive, accessible pathway to better outcomes and improved quality of life.
The clinic’s initial rollout in Indiana and Maryland will serve as the foundation for nationwide expansion in 2026, with partnerships under development with leading health systems.
Brendan Staunton is CEO of Amara Therapeutics.
He said: “Dry Days Health isn’t just improving access to care, it’s redefining how women engage with their health.
“With Dry Days Health, we’re proving that accessible, high-quality pelvic health care can scale nationally.
“We’re building a model that makes specialist women’s care intuitive and connected, improving outcomes for patients and efficiency for providers.”
To learn more or to book an appointment, visit www.drydays.health
Cancer
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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