News
£4m funding to improve conception chances in women over 35
Ovo Labs has developed three methods to rejuvenate human eggs as women get older – securing £4m in seed funding for its launch.
As women age, their ability to produce healthy eggs declines sharply. By the time a woman reaches 40, over 70 per cent of her eggs carry genetic abnormalities. This makes conception significantly harder. Unfortunately, even the gold-standard treatment for infertility, IVF, fails for eight out of 10 women in their late 30s, leaving tens of millions of couples each year unable to start a family.
Successful conception through IVF often relies on patients undergoing as many as half a dozen IVF cycles, each with a low success rate. In contrast, Ovo Labs aims to dramatically increase the number of women who can conceive in a single IVF attempt by addressing poor egg quality – a significant factor in female infertility and IVF success.
Ovo Labs aims to dramatically increase the number of women who can conceive in a single IVF attempt by addressing this bottleneck — poor egg quality.
The company is spearheading the development of new therapeutics that reduce genetic errors in eggs (aneuploidy), thereby increasing the number of viable eggs that can be successfully used for fertility treatment.
The round, co-led by Creator Fund and Local Globe and with participation of Blue Wire Capital, Ahren Innovation Capital and Antonio Pellicer (founder of the world’s largest IVF clinic chain), allows Ovo Labs to further develop its therapeutics and put them in pole position to advance towards clinical trials.
Professor Melina Schuh, Ovo Labs co-founder and scientific advisor, said: “Ovo Labs’ mission is to make the dream of parenthood a reality for millions of couples who struggle to conceive. By helping to increase the number of viable eggs, we aim to extend the reproductive window, empowering more couples to have children at a time that feels right to them.
“Ovo Labs’ technology also offers a potential solution for declining birth rates, which is a trend observed in many countries worldwide.”
Ovo Lab’s work in pioneering therapeutics has been shown to significantly cut genetic errors in eggs (aneuploidy), thereby increasing the number of viable eggs that can be successfully used for fertility treatment. Once approved by regulatory authorities, this treatment can be seamlessly integrated into the standard IVF workflow, at no extra burden to the patient while offering hope for the transformation of infertility treatment.
The firm’s technology builds on the pioneering research of Professor Melina Schuh, a world-renowned fertility expert at the Max Planck Institute. She is joined by co-founder Dr. Agata Zielinska, a highly accomplished fertility scientist. Completing their team is Dr. Oleksandr Yagensky, a biologist-turned-strategy consultant and one of the fastest-promoted scientific hires in the history of Bain & Company in Germany.
Using cutting-edge microscopes and molecular tools, Melina and Agata first pioneered meticulous studies on young and older eggs at Bourn Hall Clinic, the world’s first IVF centre, whose founding team’s work was recently spotlighted in the Netflix movie Joy.
Ovo Labs has now proven that they can improve the quality of eggs in old mice and have secured an attractive IP package and shown they can successfully treat isolated human eggs. As they enter the next stage, their product development will be carried out at the state-of-the-art facility at the Life Science Factory in Munich.
Jamie Macfarlane from Creator Fund, said: “This company has been twenty years in the making. It is the product of decades of pioneering scientific work to understand the origin of human life and why age impacts our ability to reproduce. It is inspiring to see European scientists of this calibre launch a company solving such a fundamental question facing humanity.
“We believe that the science at the heart of this business has the potential to change whether, when and how couples have children.”
Emma Phillips, investment partner at Local Globe, who co-led the investment, said: “Women and couples deserve better odds of IVF success, which Ovo Labs delivers. LocalGlobe is thrilled to support this team of world leading scientists tackling the core challenges of fertility with groundbreaking solutions.”
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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