News
Jude raises €2.4 million to break stigma around bladder issues
The funding is the highest pre-seed round raised in the UK by solo female founder
The female-founded company, Jude has raised €2.4 million to break the stigma around bladder issue products such as pads, liners and supplements.
The funding is the highest pre-seed round raised in the UK by solo female founder, Peony Li. Around one in every three women or 14 million people in the UK struggle with bladder control issues although, despite this, potential investors did not want to invest. The company has now secured the backing of 12 female investors and Reckitt’s Innovation fund Access VC.
The announcement was made on International Women’s Day which focused on #BreakingtheBias for 2022. This funding represents a change in the way female-founded companies or start-ups tackling female health are viewed.
Peony Li, Founder, Jude said: “Over 14 million of us experience problems with our bladders, so why do we continue to suffer in silence? I want to break the stigma around bladder care and create a community and brand that makes people feel heard, seen and supported. I know I’ll have succeeded when we all start having conversations about incontinence in the same way we talk about periods and menopause.”
Jude products
One of the benefits of using Jude is that the products are biodegradable. Period care waste is a huge problem, people with periods use more than 11,000 disposable menstrual products in their lifetime which is based on the average of 38 years of menstruation using 22 items of sanitary products per cycle, 13 cycles per year. There are also issues around the adhesive, which uses harmful chemicals and petrochemical additives, applied to pads to help them stay in place. Jude uses plant-based, degradable materials and focuses on reducing its footprint.
Since their launch in January 2022, the company has shipped its products to 2,600 customers. It also provides clinically tested supplements that have been co-created with a community of 300 women. Its pre-seed funding will help to further develop its innovative solutions and also run large scale clinical supplement trials. It will also allow for expansion by hiring more staff and investment into education content aimed at breaking the stigma around bladder health.
Read more: Could femtech offer creative solutions for women seeking abortion care?
Diagnosis
Lung cancer drug shows breast cancer potential
Ovarian cancer cells quickly activate survival responses after PARP inhibitor treatment, and a lung cancer drug could help block this, research suggests.
PARP inhibitors are a common treatment for ovarian cancer, particularly in tumours with faulty DNA repair. They stop cancer cells fixing DNA damage, which leads to cell death, but many tumours later stop responding.
Researchers identified a way cancer cells may survive PARP inhibitor treatment from the outset, pointing to a potential way to block that response. A Mayo Clinic team found ovarian cancer cells rapidly switch on a pro-survival programme after exposure to PARP inhibitors. A key driver is FRA1, a transcription factor (a protein that turns genes on and off) that helps cancer cells adapt and avoid death.
The team then tested whether brigatinib, a drug approved for certain lung cancers, could block this response and boost the effect of PARP inhibitors. Brigatinib was chosen because it inhibits multiple signalling pathways involved in cancer cell survival.
In laboratory studies, combining brigatinib with a PARP inhibitor was more effective than either treatment alone. Notably, the effect was seen in cancer cells but not normal cells, suggesting a more targeted approach.
Brigatinib also appeared to act in an unexpected way. Rather than working through the usual DNA repair routes, it shut down two signalling molecules, FAK and EPHA2, that aggressive ovarian cancer cells rely on. FAK and EPHA2 are proteins that relay survival signals inside cells. Blocking both at once weakened the cells’ ability to adapt and resist treatment, making them more vulnerable to PARP inhibitors.
Tumours with higher levels of FAK and EPHA2 responded better to the drug combination. Other data link high levels of these molecules to more aggressive disease, pointing to potential benefit in harder-to-treat cases.
Arun Kanakkanthara, an oncology investigator at Mayo Clinic and a senior author of the study, said: “This work shows that drug resistance does not always emerge slowly over time; cancer cells can activate survival programmes very early after treatment begins.”
John Weroha, a medical oncologist at Mayo Clinic and a senior author of the study, said: “From a clinical perspective, resistance remains one of the biggest challenges in treating ovarian cancer. By combining mechanistic insights from Dr Kanakkanthara’s laboratory with my clinical experience, this preclinical work supports the strategy of targeting resistance early, before it has a chance to take hold. This strategy could improve patient outcomes.”
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